Human Feasibility Study of Fluorescence Spectroscopy Guided Optical Biopsy Needle for Prostate Cancer Diagnosis

IEEE Engineering in Medicine and Biology Society, 37th Annual Conference

08/28/15

Current prostate biopsy cores have a very low diagnostic yield. These biopsies often fail to diagnose prostate cancer since 90% of cores are histopathologically classified as benign. The concentrations of endogenous fluorophores in prostate tissue vary with disease states. Thus, fluorescence spectroscopy could be utilized to quantify these variations for identification of malignant lesions.

Fluorescence Spectroscopy Can Increase Diagnostic Yield of Prostate Biopsies*

The Journal of Urology®, Vol. 193, No. 4S, Supplement

05/17/2015

Transrectal ultrasound (TRUS) guided prostate biopsy cores have a very low diagnostic yield as 90% cores are histopathologically classified as benign. We investigated potential clinical application fluorescence spectroscopy (FS) to increase diagnostic yield of TRUS biopsies.

Systematic Diagnosis of Prostate Cancer Using an Optical Biopsy Needle Adjunct with Fluorescence Spectroscopy

IEEE Engineering in Medicine and Biology Society Conference

08/26/2014

Transrectal ultrasound guided prostate biopsies often fail to diagnose prostate cancer with 90% of cores reported as benign. Thus, it is desirable to target prostate cancer lesions while reducing the sampling of benign tissue.

Diagnosis of High-grade Prostatic Cancer Using Diffuse Reflectance Spectroscopy

The Journal of Urology, Vol. 191, No. 4S, Supplement

05/19/2014

High grade (HG) prostatic carcinoma (PCa) that includes Gleason patterns 4 and 5 indicate worse clinical outcome for patients. Due to sampling errors, transrectal ultrasound guided prostate biopsies often fail to diagnose HG PCa.

Minimally Invasive 16G Optical Biopsy Needle for Prostate Cancer Diagnosis*

The Journal of Urology, Vol. 185, No. 4S, Supplement

05/18/2011

Random transrectal prostate biopsies often fail to diagnose prostate cancer (PCa) and to accurately grade and stage this disease. The concentrations of natural fluorophores (e.g., tryptophan) in prostate tissue fluctuate with disease states.

Fluorescence Spectroscopy: An Adjunct Diagnostic Tool to Image-Guided Core Needle Biopsy of the Breast

IEEE Transactions on Biomedical Engineering, Vol. 56, No. 10

10/2009

We explored the use of a fiber-optic probe for in vivo fluorescence spectroscopy of breast tissues during percutaneous image-guided breast biopsy. A total of 121 biopsy samples with accompanying histological diagnosis were obtained clinically and investigated in this study.

In vivo Light Scattering for the Detection of Cancerous and Precancerous Lesions of the Cervix

Applied Optics, Vol. 48, No. 10

04/01/2009

A noninvasive optical diagnostic system for detection of cancerous and precancerous lesions of the cervix was evaluated in vivo. The optical system included a fiber-optic probe designed to measure polarized and unpolarized light transport properties of a small volume of tissue.

Autofluorescence and Diffuse Reflectance Properties of Malignant and Benign Breast Tissues

Annals of Surgical Oncology, Vol. 11, No. 1

08/25/2003

Fluorescence spectroscopy is an evolving technology that can rapidly differentiate between benign and malignant tissues. These differences are thought to be due to endogenous fluorophores, including nicotinamide adenine dinucleotide, flavin adenine dinucleotide…

Elastic Scattering Spectroscopy for Detection of Prostate Cancer: Preliminary Feasibility Study

Diagnostic Optical Spectroscopy in Biomedicine II, SPIE Vol. 5141

2003

We have conducted a preliminary study of the potential for diagnostic spectroscopy based on elastic light scattering to serve as a method for optically-guided biopsy to reduce sampling errors and thereby improve sensitivity, in detecting prostate cancer.

*Received 1st place award in Screening and Detection session