Human Feasibility Study of Fluorescence Spectroscopy Guided Optical Biopsy Needle for Prostate Cancer Diagnosis
IEEE Engineering in Medicine and Biology Society, 37th Annual Conference
Current prostate biopsy cores have a very low diagnostic yield. These biopsies often fail to diagnose prostate cancer since 90% of cores are histopathologically classified as benign. The concentrations of endogenous fluorophores in prostate tissue vary with disease states. Thus, fluorescence spectroscopy could be utilized to quantify these variations for identification of malignant lesions.
The Journal of Urology®, Vol. 193, No. 4S, Supplement
Transrectal ultrasound (TRUS) guided prostate biopsy cores have a very low diagnostic yield as 90% cores are histopathologically classified as benign. We investigated potential clinical application fluorescence spectroscopy (FS) to increase diagnostic yield of TRUS biopsies.
Systematic Diagnosis of Prostate Cancer Using an Optical Biopsy Needle Adjunct with Fluorescence Spectroscopy
IEEE Engineering in Medicine and Biology Society Conference
Transrectal ultrasound guided prostate biopsies often fail to diagnose prostate cancer with 90% of cores reported as benign. Thus, it is desirable to target prostate cancer lesions while reducing the sampling of benign tissue.
The Journal of Urology, Vol. 191, No. 4S, Supplement
High grade (HG) prostatic carcinoma (PCa) that includes Gleason patterns 4 and 5 indicate worse clinical outcome for patients. Due to sampling errors, transrectal ultrasound guided prostate biopsies often fail to diagnose HG PCa.
The Journal of Urology, Vol. 185, No. 4S, Supplement
Random transrectal prostate biopsies often fail to diagnose prostate cancer (PCa) and to accurately grade and stage this disease. The concentrations of natural fluorophores (e.g., tryptophan) in prostate tissue fluctuate with disease states.
Fluorescence Spectroscopy: An Adjunct Diagnostic Tool to Image-Guided Core Needle Biopsy of the Breast
IEEE Transactions on Biomedical Engineering, Vol. 56, No. 10
We explored the use of a fiber-optic probe for in vivo fluorescence spectroscopy of breast tissues during percutaneous image-guided breast biopsy. A total of 121 biopsy samples with accompanying histological diagnosis were obtained clinically and investigated in this study.
Applied Optics, Vol. 48, No. 10
A noninvasive optical diagnostic system for detection of cancerous and precancerous lesions of the cervix was evaluated in vivo. The optical system included a fiber-optic probe designed to measure polarized and unpolarized light transport properties of a small volume of tissue.
Annals of Surgical Oncology, Vol. 11, No. 1
Fluorescence spectroscopy is an evolving technology that can rapidly differentiate between benign and malignant tissues. These differences are thought to be due to endogenous fluorophores, including nicotinamide adenine dinucleotide, flavin adenine dinucleotide…
Diagnostic Optical Spectroscopy in Biomedicine II, SPIE Vol. 5141
We have conducted a preliminary study of the potential for diagnostic spectroscopy based on elastic light scattering to serve as a method for optically-guided biopsy to reduce sampling errors and thereby improve sensitivity, in detecting prostate cancer.
*Received 1st place award in Screening and Detection session